Phospholipase D-catalyzed trans-alkylphosphorylation. A facile one-step synthesis of nucleoside 5'-alkylphosphates.
نویسندگان
چکیده
منابع مشابه
Facile synthesis of 5-substituted-1H-tetrazoles catalyzed by reusable nickel zirconium phosphate nanocatalyst
5-Substituted-1H-tetrazoles were synthesized by the [3 + 2] cycloaddition of sodium azide with various nitriles in the presence of nickel zirconium phosphate (NiZrP) as an effective heterogeneous catalyst in dimethylsulfoxide at 120 °C. This method has the advantages of good to high yields, simple methodology and easy work-up. The catalyst can be recovered by centrifuging and reused with good y...
متن کاملFacile synthesis of 5-substituted-1H-tetrazoles catalyzed by reusable nickel zirconium phosphate nanocatalyst
5-Substituted-1H-tetrazoles were synthesized by the [3 + 2] cycloaddition of sodium azide with various nitriles in the presence of nickel zirconium phosphate (NiZrP) as an effective heterogeneous catalyst in dimethylsulfoxide at 120 °C. This method has the advantages of good to high yields, simple methodology and easy work-up. The catalyst can be recovered by centrifuging and reused with good y...
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Nucleoside 5'-triphosphates (NTPs) play key roles in biology and medicine. However, these compounds are notoriously difficult to synthesize. We describe a one-pot method to prepare NTPs from nucleoside 5'-H-phosphonate monoesters via pyridinium phosphoramidates, and we used this approach to synthesize ATP, UTP, GTP, CTP, ribavirin-TP, and 6-methylpurine ribonucleoside-TP (6MePTP). Poliovirus RN...
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For the first time, the L-proline-catalyzed direct asymmetric self-aldolization of acetaldehyde is described affording (+)-(5S)-hydroxy-(2E)-hexenal 2 with ee's ranging from 57 to 90%. Further transformations of 2 into synthetically valuable building blocks are presented. A mechanism for the formation of 2 is proposed.
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5-Substituted and 5,5-disubstituted hydantoins are synthesised from the corresponding aldehydes or ketones, using a one-pot, gallium(III) triflate-catalysed procedure that is compatible with a range of substrates and solvents.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1988
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.36.5020